Parkinson’s disease otherwise known as PD is one of the most complex disorders of the human neurological system. Clinical studies into this health disorder encompass the epidemiological, and also all genetic subtypes. With Parkinson’s disease, patients diagnosed with the disease will experience dopaminergic neurons depletion. Thus, causing the substantia nigra depletion of striatal dopamine. This structure, according to health studies, is the underlying or main mechanism of the motor features found in patients with PD.
Where Parkinson’s disease is diagnosed, it showed that neurotransmitter changes are the most notable when dopamine depletion occurs. And although the depletion of dopamine remains the most common, there are other changes of neurochemical changes that will over time show symptoms that contribute to PD.
Parkinson’s disease is known to affect several parts of the human body’s nervous system. Clinical studies show that the outside region of the basal ganglia is also prone to PD. Molecular pathogenesis is the underlying pathway that involves multiple mechanisms. Those are identified as axonal transport, α-synuclein proteostasis, neuroinflammation, mitochondrial function, oxidative stress, and calcium homeostasis.
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